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Targeting MBLAC1 for the Treatment of Substance Abuse

Through a vast array of experiments, FAU researchers have discovered that ceftriaxone (CEF) is a high affinity binding partner with MBLAC1 and may be responsible for its neuroprotective properties. Mice were genetically modified to lack the MBLAC1 gene and compared to normal mice after the administration of cocaine. The mice lacking MBLAC1 had significantly...

Published: 8/2/2019 | Inventor(s): Randy Blakely, Maureen Hahn

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Category(s): Genetics

Mouse Model to Study the Psychostimulant-Ceftriaxone Axis

FAU researchers have effectively knocked out the MBLAC1 gene in mice. It has been shown that the human MBLAC1 protein binds directly to ceftriaxone (CEF), which is known to interfere with the activity and addictive properties of several commonly abused drugs, potentially curbing drug-seeking behavior. Thus, mice given cocaine are extremely hyperactive...

Published: 4/14/2021 | Inventor(s): Randy Blakely, Maureen Hahn

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Category(s): Genetics